Published: Apr 17, 2026
Published: Apr 16, 2026
Published: Apr 16, 2026
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Authors: Gauvin N, Wayne B, Mathew-Steiner SS, Jones TLZ, Pop-Busui R, Spino C, Maturo F, Schmidt BM, Holmes C, Sen CK, Semere W Abstract Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite significant... <a class="view-article" href="https://pitt.creatotech.com/partnering-with-communities-to-improve-diabetic-foot-ulcer-care-in-high-risk-populations/">View Article</a>
Read MoreAuthors: Lathrop KL, Coelho JT, Chandran C, Ali SR, Geary ML, Dhaliwal DK, Jhanji V, Santra M, Yam GHF Abstract Corneal fibrosis, clinically referred to as corneal scarring, disrupts the normal architecture and transparency of the cornea and remains a major cause of visual impairment worldwide. Although corneal transplantation can restore vision, its effectiveness is... <a class="view-article" href="https://pitt.creatotech.com/human-corneal-stromal-stem-cell-treatment-reduces-established-opacities-in-chronic-corneal-scarring/">View Article</a>
Read MoreAuthors: Silva-Mendonça S, Seanego D, Jurisch C, Mottin M, Nader Motta F, S A Rodrigues B, S M Junior G, Dos Santos Carvalho AM, Muniz de Oliveira F, Sigurdardóttir S, Sunnerhagen P, Marques Dourado Bastos I, Gessner R, Chibale K, Horta Andrade C Abstract The SARS-CoV-2 3-chymotrypsin-like (3CL) protease is a key target for the... <a class="view-article" href="https://pitt.creatotech.com/structure-and-ligand-based-discovery-of-novel-3-chymotrypsin-like-protease-nonpeptidomimetic-hits/">View Article</a>
Read MoreAuthors: Sen CK, Roy S Abstract Barrier function of human skin maintains hydration by preventing excessive transepidermal water loss (TEWL), blocks the entry of pathogens and allergens, regulates thermal and chemical exchange with the environment, and sustains immune equilibrium. A wound arises when this barrier is breached, resulting in a loss of structural integrity and... <a class="view-article" href="https://pitt.creatotech.com/the-invisible-wound-silent-focal-breach-of-skin-integrity-that-cascades-into-systemic-dysfunction-and-chronic-morbidity/">View Article</a>
Read MoreAuthors: Fitz NF, Kumar A, Su Y, Sharma M, Singh S, Koldamova R, Lefterov I, Sahu A, Ambrosio F, Rosano C, Deep G Abstract Mobility decline with aging is a major health concern, associated with a higher risk for disability. Despite the prevalence of gait slowing in elderly adults, this issue has not been adequately... <a class="view-article" href="https://pitt.creatotech.com/serum-derived-extracellular-vesicles-as-biological-indicator-of-mobility-resilience-in-older-adults/">View Article</a>
Read MoreAuthors: Maestas DR, Murphy TR, Martinet KM, Moyston T, Min LX, Behrangzade A, Pemberton BJ, Joy J, Ye SH, Hussey GS, Azhar M, Wagner WR, Geest JPV Abstract The long-term performance of tissue-engineered scaffolds, particularly small-diameter vascular grafts, is shaped by remodeling events at the tissue-graft interface, yet these processes remain difficult to resolve longitudinally... <a class="view-article" href="https://pitt.creatotech.com/resolving-differential-vascular-graft-remodeling-using-longitudinal-multiphoton-tracking-in-a-3d-culture-platform/">View Article</a>
Read MoreAuthors: Gokhale TA, Dey S, Limpitikul WB, Gautam N, Al'Aref SJ, Cross B, Saba S, Estes NAM, Vaughan BL, Jones SR, Tomaselli GF, Wu KC, DeMazumder D Abstract Accurate selection of patients who will benefit from a primary-prevention implantable cardioverter-defibrillator (ICD) remains a challenge. Cardiac magnetic resonance imaging (CMR) of myocardial tissue heterogeneity and EntropyX,... <a class="view-article" href="https://pitt.creatotech.com/combined-analysis-of-cardiac-repolarization-entropy-and-magnetic-resonance-imaging-enhances-risk-stratification-of-patients-receiving-a-primary-prevention-icd-3/">View Article</a>
Read MoreAuthors: Wellman SM, Guzman K, Suematsu N, Thai T, Tung TH, Padilla CG, Sridhar S, Chen K, Cambi F, Kozai TDY Abstract Loss of oligodendrocytes (OLs) and myelin impairs neuronal firing and network stability, whereas enhancing oligodendrogenesis with clemastine improves electrophysiological stability in cortex and, to a lesser extent, hippocampus. Conditional depletion ofin OLs (cKO)... <a class="view-article" href="https://pitt.creatotech.com/oligodendrocyte-specificdepletion-preserves-ca1-single-unit-fidelity-and-stabilizes-network-dynamics-during-chronic-recording/">View Article</a>
Read MoreAuthors: Bukkuri A, McLaughlin J, Duncan AW, Stallaert W Abstract Life history enlightened therapies (LHETs) were originally developed in cancer to combat therapeutic resistance by targeting pathological cell state transitions that enable evolutionary rescue and adaptation to therapy. In this paper, we expand the scope of LHETs to cancer prevention, namely, metabolic dysfunction-associated steatohepatitis (MASH)-induced... <a class="view-article" href="https://pitt.creatotech.com/life-history-enlightened-therapies-cell-cycle-mapping-to-identify-molecular-targets-to-prevent-hepatocellular-carcinoma-2/">View Article</a>
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