Published: May 7, 2026
Published: May 7, 2026
Published: May 7, 2026
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Authors: Suematsu N, Vazquez AL, Kozai TD Abstract Understanding the chronic effects of intracortical microstimulation (ICMS) and device implantation on cortical function is essential for the development of stable neuroprosthetics. We chronically implanted penetrating microelectrodes into Thy1-GCaMP6s mice and conducted longitudinal mesoscopic widefield and two-photon Ca imaging alongside intrinsic optical signal recordings over 12 weeks.... <a class="view-article" href="https://pitt.creatotech.com/chronic-alteration-of-ca-and-hemodynamic-signals-induced-by-intracortical-microstimulation-in-the-visual-cortex-of-awake-mice/">View Article</a>
Read MoreAuthors: Lopes-Ribeiro Á, Marques-Ferreira G, Pereira Araujo F, de Melo Oliveira P, Lourenço AA, Cardoso Corrêa-Dias L, Pereira Santos TA, Wilker Teixeira C, Gomes de Pontes L, de Melo Rocha V, de Sousa Reis EV, Henriques Pereira S, Alves Oliveira Paim A, Flores Andrade LA, Martins da Mata CPS, Guimarães da Fonseca F, Santos Coelho... <a class="view-article" href="https://pitt.creatotech.com/immune-landscape-of-covid-19-recovery-nucleocapsid-as-a-major-target-of-cd8-t-cell-antiviral-responses-in-convalescent-hla-a2-individuals-from-brazil/">View Article</a>
Read MoreAuthors: Butler M, Maywar A, Orizondo R, Federspiel W, Kim-Campbell N Abstract In extracorporeal therapies such as cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO), the transport of blood through artificial circulation frequently results in the rupture of erythrocytes, releasing hemoglobin (Hb) into the plasma (fHb), and exhausting the body's supply of the natural fHb... <a class="view-article" href="https://pitt.creatotech.com/development-of-a-plasma-free-hemoglobin-adsorbing-device-for-extracorporeal-therapies/">View Article</a>
Read MoreAuthors: Charles KL, Xing Y, Otto EL, Ren X, Campbell PG, Vorp DA, Weinbaum JS Abstract Silk fibroin (SF) is an ideal biomaterial for next-generation clinical wound dressings due to its biocompatibility and tunable mechanical properties. Cell therapies for wound healing have explored using SF as the base for delivering beneficial cargo; however, retention is... <a class="view-article" href="https://pitt.creatotech.com/amine-reactive-augmentation-of-silk-fibroin-mats-for-increasing-cargo-retention-capabilities/">View Article</a>
Read MoreAuthors: Acharya AP, Borrelli MA, Jurczak MJ, Krakoff J, Little SR Abstract Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual's own microbiota to enhance lipid metabolism is presented, which is based on sequential culture of these bacteria... <a class="view-article" href="https://pitt.creatotech.com/lipid-stress-evolved-microbiome-based-probiotics-reduce-lipid-uptake-in-mice/">View Article</a>
Read MoreAuthors: Harding PA, Westbay JH, Fletcher E, Fan X, DiLeo MV Abstract Current systems for topical ocular drug delivery enable non-invasive administration of therapeutics to the eye but suffer from poor permeability and bioavailability, limiting therapeutic efficacy. Metal-organic frameworks are porous, crystalline materials that can serve as drug delivery systems and may improve these shortcomings.... <a class="view-article" href="https://pitt.creatotech.com/zeolitic-imidazolate-frameworks-zif-8-as-a-carrier-in-a-topical-ocular-delivery-system-for-the-treatment-of-ocular-diseases/">View Article</a>
Read MoreAuthors: Gauvin N, Wayne B, Mathew-Steiner SS, Jones TLZ, Pop-Busui R, Spino C, Maturo F, Schmidt BM, Holmes C, Sen CK, Semere W Abstract Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite significant... <a class="view-article" href="https://pitt.creatotech.com/partnering-with-communities-to-improve-diabetic-foot-ulcer-care-in-high-risk-populations/">View Article</a>
Read MoreAuthors: Lathrop KL, Coelho JT, Chandran C, Ali SR, Geary ML, Dhaliwal DK, Jhanji V, Santra M, Yam GHF Abstract Corneal fibrosis, clinically referred to as corneal scarring, disrupts the normal architecture and transparency of the cornea and remains a major cause of visual impairment worldwide. Although corneal transplantation can restore vision, its effectiveness is... <a class="view-article" href="https://pitt.creatotech.com/human-corneal-stromal-stem-cell-treatment-reduces-established-opacities-in-chronic-corneal-scarring/">View Article</a>
Read MoreAuthors: Silva-Mendonça S, Seanego D, Jurisch C, Mottin M, Nader Motta F, S A Rodrigues B, S M Junior G, Dos Santos Carvalho AM, Muniz de Oliveira F, Sigurdardóttir S, Sunnerhagen P, Marques Dourado Bastos I, Gessner R, Chibale K, Horta Andrade C Abstract The SARS-CoV-2 3-chymotrypsin-like (3CL) protease is a key target for the... <a class="view-article" href="https://pitt.creatotech.com/structure-and-ligand-based-discovery-of-novel-3-chymotrypsin-like-protease-nonpeptidomimetic-hits/">View Article</a>
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