Published: Jun 6, 2026
Published: Jun 6, 2026
Published: Jun 5, 2026
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Authors: Swanson WB, Wu DT, Yoshida M, Ambruster J, Sfeir CS, Wagner WR, Mooney DJ, Giannobile WV, Kohn DH Abstract Dental, oral, and craniofacial regenerative medicine has benefitted from fundamental scientific discoveries, yet the resulting technologies and therapies do not always generate the anticipated clinical impact. Despite robust progress and substantial investment in biomaterials and... <a class="view-article" href="https://pitt.creatotech.com/driving-emerging-technology-to-clinical-impact/">View Article</a>
Read MoreAuthors: Edmunds KJ, Porter EC, Lai YR, Guyette J, Williams C, Jaiganesh A, Ott H, Weinbaum JS, Black LD Abstract The development of regenerative strategies to repair the heart is of high importance. Our lab has shown that extracellular matrix derived from decellularized fetal myocardium promotes neonatal cardiomyocyte proliferation in vitro. The goal of this... <a class="view-article" href="https://pitt.creatotech.com/identification-and-characterization-of-a-fibrillin-1-derived-matrikine-for-cardiac-regeneration-and-repair/">View Article</a>
Read MoreAuthors: Schreib CC, Kelley EL, Audia G, Garg R, Johnson S, Fleury S, Behun MN, Vohidova D, Kulkarni M, Donnell GM, Brown BN, Badylak SF, Cohen-Karni T, Veiseh O Abstract Wounds can become chronic if the biological processes that coordinate tissue repair, including immune cell activity and matrix remodelling, become dysregulated. Current treatments mainly focus... <a class="view-article" href="https://pitt.creatotech.com/cell-based-cytokine-patch-for-localized-immunomodulation-and-accelerated-healing-in-rodent-and-porcine-wounds/">View Article</a>
Read MoreAuthors: Wu B, Castagnola E, Robbins E, Kaminsky M, Sanker S, McClung CA, Cui XT Abstract The circadian rhythm regulates physiological and behavioral processes, with disruptions linked to metabolic and neuropsychiatric disorders. Circadian genes play a crucial role in the regulation of dopaminergic signaling, yet the underlying molecular mechanisms remain unclear. This study investigates how... <a class="view-article" href="https://pitt.creatotech.com/tonic-dopamine-sensing-reveals-a-d2-and-d3-mediated-dopamine-response-to-raclopride-in-%ce%b4-mice-model/">View Article</a>
Read MoreAuthors: Borrelli MA, Warunek JJP, Ann Varghese B, Turner N, Little SR, Turnquist HR Abstract Skeletal muscle injuries are a common consequence of physical activity, repetitive movements, and trauma. Regulatory T cells (Treg) act as critical mediators of immune repair response after injury. Thus, treatments effectively targeting Treg may accelerate injury resolution. CCL22 is a... <a class="view-article" href="https://pitt.creatotech.com/regulatory-t-cell-attracting-therapy-accelerates-skeletal-muscle-functional-recovery-following-injury/">View Article</a>
Read MoreAuthors: Gilmer G, Hall AJ, Kargl CK, El-Mossier SO, Balaji S, Hussey GS, Artsen AM, Koltun KJ, Sahu A Abstract Oral contraceptive pills (OCPs) are one of the most prescribed medications, yet we lack an understanding of if and how OCPs affect non-reproductive tissues. Given the well-documented effects of sex hormones on skeletal muscle, including... <a class="view-article" href="https://pitt.creatotech.com/beyond-birth-control-how-oral-contraceptives-impact-skeletal-muscle-health-a-systematic-review-and-meta-analysis/">View Article</a>
Read MoreAuthors: Enguita FJ, Leitão AL, Beheshti A Abstract When living organisms are exposed to the space environment, numerous changes occur that affect virtually all cellular functions and molecular pathways. One class of understudied molecules in space biomedicine is noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs). Given that spaceflight induces systemic health risks, miRNAs represent natural candidates... <a class="view-article" href="https://pitt.creatotech.com/a-systems-biology-approach-to-discovery-and-validation-of-microrna-signature-health-risks-associated-with-the-space-environment/">View Article</a>
Read MoreAuthors: Bhasme P, Singh S, Mathew Steiner SS, Roy S, Sen CK Abstract Wound healing emerges from a tightly orchestrated bioelectric landscape shaped by ion gradients, membrane potentials, and redox dynamics physical cues that direct cell migration, immune activation, and epithelial organization long before biochemical gradients take form. Recent advances reveal that electrical signals constitute... <a class="view-article" href="https://pitt.creatotech.com/electrochemical-modulation-of-host-microbe-dynamics-in-wound-healing/">View Article</a>
Read MoreAuthors: Suematsu N, Vazquez AL, Kozai TD Abstract Understanding the chronic effects of intracortical microstimulation (ICMS) and device implantation on cortical function is essential for the development of stable neuroprosthetics. We chronically implanted penetrating microelectrodes into Thy1-GCaMP6s mice and conducted longitudinal mesoscopic widefield and two-photon Ca imaging alongside intrinsic optical signal recordings over 12 weeks.... <a class="view-article" href="https://pitt.creatotech.com/chronic-alteration-of-ca-and-hemodynamic-signals-induced-by-intracortical-microstimulation-in-the-visual-cortex-of-awake-mice/">View Article</a>
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