Published: May 4, 2026
Published: May 4, 2026
Published: May 4, 2026
Help the McGowan Institute Grow and Succeed: Your philanthropic support ensures the McGowan Institute for Regenerative Medicine will continue to grow and succeed. You are crucial to our efforts to develop tomorrow’s therapies and science and medical leaders.
Authors: Butler M, Maywar A, Orizondo R, Federspiel W, Kim-Campbell N Abstract In extracorporeal therapies such as cardiopulmonary bypass (CPB) or extracorporeal membrane oxygenation (ECMO), the transport of blood through artificial circulation frequently results in the rupture of erythrocytes, releasing hemoglobin (Hb) into the plasma (fHb), and exhausting the body's supply of the natural fHb... <a class="view-article" href="https://pitt.creatotech.com/development-of-a-plasma-free-hemoglobin-adsorbing-device-for-extracorporeal-therapies/">View Article</a>
Read MoreAuthors: Charles KL, Xing Y, Otto EL, Ren X, Campbell PG, Vorp DA, Weinbaum JS Abstract Silk fibroin (SF) is an ideal biomaterial for next-generation clinical wound dressings due to its biocompatibility and tunable mechanical properties. Cell therapies for wound healing have explored using SF as the base for delivering beneficial cargo; however, retention is... <a class="view-article" href="https://pitt.creatotech.com/amine-reactive-augmentation-of-silk-fibroin-mats-for-increasing-cargo-retention-capabilities/">View Article</a>
Read MoreAuthors: Acharya AP, Borrelli MA, Jurczak MJ, Krakoff J, Little SR Abstract Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual's own microbiota to enhance lipid metabolism is presented, which is based on sequential culture of these bacteria... <a class="view-article" href="https://pitt.creatotech.com/lipid-stress-evolved-microbiome-based-probiotics-reduce-lipid-uptake-in-mice/">View Article</a>
Read MoreAuthors: Harding PA, Westbay JH, Fletcher E, Fan X, DiLeo MV Abstract Current systems for topical ocular drug delivery enable non-invasive administration of therapeutics to the eye but suffer from poor permeability and bioavailability, limiting therapeutic efficacy. Metal-organic frameworks are porous, crystalline materials that can serve as drug delivery systems and may improve these shortcomings.... <a class="view-article" href="https://pitt.creatotech.com/zeolitic-imidazolate-frameworks-zif-8-as-a-carrier-in-a-topical-ocular-delivery-system-for-the-treatment-of-ocular-diseases/">View Article</a>
Read MoreAuthors: Gauvin N, Wayne B, Mathew-Steiner SS, Jones TLZ, Pop-Busui R, Spino C, Maturo F, Schmidt BM, Holmes C, Sen CK, Semere W Abstract Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite significant... <a class="view-article" href="https://pitt.creatotech.com/partnering-with-communities-to-improve-diabetic-foot-ulcer-care-in-high-risk-populations/">View Article</a>
Read MoreAuthors: Lathrop KL, Coelho JT, Chandran C, Ali SR, Geary ML, Dhaliwal DK, Jhanji V, Santra M, Yam GHF Abstract Corneal fibrosis, clinically referred to as corneal scarring, disrupts the normal architecture and transparency of the cornea and remains a major cause of visual impairment worldwide. Although corneal transplantation can restore vision, its effectiveness is... <a class="view-article" href="https://pitt.creatotech.com/human-corneal-stromal-stem-cell-treatment-reduces-established-opacities-in-chronic-corneal-scarring/">View Article</a>
Read MoreAuthors: Silva-Mendonça S, Seanego D, Jurisch C, Mottin M, Nader Motta F, S A Rodrigues B, S M Junior G, Dos Santos Carvalho AM, Muniz de Oliveira F, Sigurdardóttir S, Sunnerhagen P, Marques Dourado Bastos I, Gessner R, Chibale K, Horta Andrade C Abstract The SARS-CoV-2 3-chymotrypsin-like (3CL) protease is a key target for the... <a class="view-article" href="https://pitt.creatotech.com/structure-and-ligand-based-discovery-of-novel-3-chymotrypsin-like-protease-nonpeptidomimetic-hits/">View Article</a>
Read MoreAuthors: Sen CK, Roy S Abstract Barrier function of human skin maintains hydration by preventing excessive transepidermal water loss (TEWL), blocks the entry of pathogens and allergens, regulates thermal and chemical exchange with the environment, and sustains immune equilibrium. A wound arises when this barrier is breached, resulting in a loss of structural integrity and... <a class="view-article" href="https://pitt.creatotech.com/the-invisible-wound-silent-focal-breach-of-skin-integrity-that-cascades-into-systemic-dysfunction-and-chronic-morbidity/">View Article</a>
Read MoreAuthors: Fitz NF, Kumar A, Su Y, Sharma M, Singh S, Koldamova R, Lefterov I, Sahu A, Ambrosio F, Rosano C, Deep G Abstract Mobility decline with aging is a major health concern, associated with a higher risk for disability. Despite the prevalence of gait slowing in elderly adults, this issue has not been adequately... <a class="view-article" href="https://pitt.creatotech.com/serum-derived-extracellular-vesicles-as-biological-indicator-of-mobility-resilience-in-older-adults/">View Article</a>
Read More