Modeling embryonic heart vascular plexus development and sympathetic innervation on a human heart organoid.

Published: 03/20/2026

Branco MA, Marzec J, Nunes MM, Bica M, Rayagra AL, Tenreiro MF, Cabral JMS, Diogo MM.
Branco MA, et al.
iScience. 2026 Feb 25;29(3):115071. doi: 10.1016/j.isci.2026.115071. eCollection 2026 Mar 20.
iScience. 2026.
PMID: 41858891
Free PMC article.

tags
Array ( [header] => Array ( [type] => esummary [version] => 0.3 ) [result] => Array ( [uids] => Array ( [0] => 41849358 [1] => 41847174 [2] => 41823943 [3] => 41803240 [4] => 41780166 ) [41849358] => Array ( [uid] => 41849358 [pubdate] => 2026 Mar 18 [epubdate] => 2026 Mar 18 [source] => PLoS Genet [authors] => Array ( [0] => Array ( [name] => Touahri Y [authtype] => Author [clusterid] => ) [1] => Array ( [name] => Pak A [authtype] => Author [clusterid] => ) [2] => Array ( [name] => David LA [authtype] => Author [clusterid] => ) [3] => Array ( [name] => Hanna J [authtype] => Author [clusterid] => ) [4] => Array ( [name] => Liu H [authtype] => Author [clusterid] => ) [5] => Array ( [name] => Xiao Y [authtype] => Author [clusterid] => ) [6] => Array ( [name] => Belfiore L [authtype] => Author [clusterid] => ) [7] => Array ( [name] => Ilnytskyy Y [authtype] => Author [clusterid] => ) [8] => Array ( [name] => van Oosten E [authtype] => Author [clusterid] => ) [9] => Array ( [name] => Tachibana N [authtype] => Author [clusterid] => ) [10] => Array ( [name] => Adnani L [authtype] => Author [clusterid] => ) [11] => Array ( [name] => Zhao J [authtype] => Author [clusterid] => ) [12] => Array ( [name] => Hoffman M [authtype] => Author [clusterid] => ) [13] => Array ( [name] => Dixit R [authtype] => Author [clusterid] => ) [14] => Array ( [name] => Zinyk D [authtype] => Author [clusterid] => ) [15] => Array ( [name] => Guidos CJ [authtype] => Author [clusterid] => ) [16] => Array ( [name] => Enzmann V [authtype] => Author [clusterid] => ) [17] => Array ( [name] => Bi P [authtype] => Author [clusterid] => ) [18] => Array ( [name] => Aubert I [authtype] => Author [clusterid] => ) [19] => Array ( [name] => Journot L [authtype] => Author [clusterid] => ) [20] => Array ( [name] => Kovalchuk I [authtype] => Author [clusterid] => ) [21] => Array ( [name] => Sauvé Y [authtype] => Author [clusterid] => ) [22] => Array ( [name] => Biernaskie J [authtype] => Author [clusterid] => ) [23] => Array ( [name] => Wang C [authtype] => Author [clusterid] => ) [24] => Array ( [name] => Okawa S [authtype] => Author [clusterid] => ) [25] => Array ( [name] => Del Sol A [authtype] => Author [clusterid] => ) [26] => Array ( [name] => Schuurmans C [authtype] => Author [clusterid] => ) ) [lastauthor] => Schuurmans C [title] => Plagl1 regulates the retinal progenitor cell to Müller glial cell transition. [sorttitle] => plagl1 regulates the retinal progenitor cell to m ller glial cell transition [volume] => 22 [issue] => 3 [pages] => e1012020 [lang] => Array ( [0] => eng ) [nlmuniqueid] => 101239074 [issn] => 1553-7390 [essn] => 1553-7404 [pubtype] => Array ( [0] => Journal Article ) [recordstatus] => PubMed - as supplied by publisher [pubstatus] => 10 [articleids] => Array ( [0] => Array ( [idtype] => pubmed [idtypen] => 1 [value] => 41849358 ) [1] => Array ( [idtype] => doi [idtypen] => 3 [value] => 10.1371/journal.pgen.1012020 ) [2] => Array ( [idtype] => pii [idtypen] => 4 [value] => PGENETICS-D-25-00207 ) ) [history] => Array ( [0] => Array ( [pubstatus] => received [date] => 2025/02/21 00:00 ) [1] => Array ( [pubstatus] => accepted [date] => 2026/01/01 00:00 ) [2] => Array ( [pubstatus] => medline [date] => 2026/03/18 18:36 ) [3] => Array ( [pubstatus] => pubmed [date] => 2026/03/18 18:36 ) [4] => Array ( [pubstatus] => entrez [date] => 2026/03/18 13:42 ) ) [references] => Array ( ) [attributes] => Array ( [0] => Has Abstract ) [pmcrefcount] => [fulljournalname] => PLoS genetics [elocationid] => doi: 10.1371/journal.pgen.1012020 [doctype] => citation [srccontriblist] => Array ( ) [booktitle] => [medium] => [edition] => [publisherlocation] => [publishername] => [srcdate] => [reportnumber] => [availablefromurl] => [locationlabel] => [doccontriblist] => Array ( ) [docdate] => [bookname] => [chapter] => [sortpubdate] => 2026/03/18 00:00 [sortfirstauthor] => Touahri Y [vernaculartitle] => ) [41847174] => Array ( [uid] => 41847174 [pubdate] => 2026 [epubdate] => 2026 Jan 14 [source] => Evol Med Public Health [authors] => Array ( [0] => Array ( [name] => Bukkuri A [authtype] => Author [clusterid] => ) [1] => Array ( [name] => McLaughlin J [authtype] => Author [clusterid] => ) [2] => Array ( [name] => Duncan AW [authtype] => Author [clusterid] => ) [3] => Array ( [name] => Stallaert W [authtype] => Author [clusterid] => ) ) [lastauthor] => Stallaert W [title] => Life history enlightened therapies: cell cycle mapping to identify molecular targets to prevent hepatocellular carcinoma. [sorttitle] => life history enlightened therapies cell cycle mapping to identify molecular targets to prevent hepatocellular carcinoma [volume] => 14 [issue] => 1 [pages] => 1-13 [lang] => Array ( [0] => eng ) [nlmuniqueid] => 101616698 [issn] => 2050-6201 [essn] => 2050-6201 [pubtype] => Array ( [0] => Journal Article ) [recordstatus] => PubMed [pubstatus] => 258 [articleids] => Array ( [0] => Array ( [idtype] => pubmed [idtypen] => 1 [value] => 41847174 ) [1] => Array ( [idtype] => pmc [idtypen] => 8 [value] => PMC12989716 ) [2] => Array ( [idtype] => pmcid [idtypen] => 5 [value] => pmc-id: PMC12989716; ) [3] => Array ( [idtype] => doi [idtypen] => 3 [value] => 10.1093/emph/eoag002 ) [4] => Array ( [idtype] => pii [idtypen] => 4 [value] => eoag002 ) ) [history] => Array ( [0] => Array ( [pubstatus] => received [date] => 2025/09/10 00:00 ) [1] => Array ( [pubstatus] => revised [date] => 2025/12/19 00:00 ) [2] => Array ( [pubstatus] => accepted [date] => 2026/01/07 00:00 ) [3] => Array ( [pubstatus] => medline [date] => 2026/03/18 07:26 ) [4] => Array ( [pubstatus] => pubmed [date] => 2026/03/18 07:25 ) [5] => Array ( [pubstatus] => entrez [date] => 2026/03/18 04:38 ) [6] => Array ( [pubstatus] => pmc-release [date] => 2026/01/14 00:00 ) ) [references] => Array ( ) [attributes] => Array ( [0] => Has Abstract ) [pmcrefcount] => 79 [fulljournalname] => Evolution, medicine, and public health [elocationid] => doi: 10.1093/emph/eoag002 [doctype] => citation [srccontriblist] => Array ( ) [booktitle] => [medium] => [edition] => [publisherlocation] => [publishername] => [srcdate] => [reportnumber] => [availablefromurl] => [locationlabel] => [doccontriblist] => Array ( ) [docdate] => [bookname] => [chapter] => [sortpubdate] => 2026/01/14 00:00 [sortfirstauthor] => Bukkuri A [vernaculartitle] => ) [41823943] => Array ( [uid] => 41823943 [pubdate] => 2026 Feb 24 [epubdate] => 2026 Feb 24 [source] => JACC Clin Electrophysiol [authors] => Array ( [0] => Array ( [name] => Gokhale TA [authtype] => Author [clusterid] => ) [1] => Array ( [name] => Dey S [authtype] => Author [clusterid] => ) [2] => Array ( [name] => Limpitikul WB [authtype] => Author [clusterid] => ) [3] => Array ( [name] => Gautam N [authtype] => Author [clusterid] => ) [4] => Array ( [name] => Al'Aref SJ [authtype] => Author [clusterid] => ) [5] => Array ( [name] => Cross B [authtype] => Author [clusterid] => ) [6] => Array ( [name] => Saba S [authtype] => Author [clusterid] => ) [7] => Array ( [name] => Estes NAM 3rd [authtype] => Author [clusterid] => ) [8] => Array ( [name] => Vaughan BL [authtype] => Author [clusterid] => ) [9] => Array ( [name] => Jones SR [authtype] => Author [clusterid] => ) [10] => Array ( [name] => Tomaselli GF [authtype] => Author [clusterid] => ) [11] => Array ( [name] => Wu KC [authtype] => Author [clusterid] => ) [12] => Array ( [name] => DeMazumder D [authtype] => Author [clusterid] => ) ) [lastauthor] => DeMazumder D [title] => Combined Analysis of Cardiac Repolarization Entropy and Magnetic Resonance Imaging Enhances Risk Stratification of Patients Receiving a Primary-Prevention ICD. [sorttitle] => combined analysis of cardiac repolarization entropy and magnetic resonance imaging enhances risk stratification of patients receiving a primary prevention icd [volume] => [issue] => [pages] => [lang] => Array ( [0] => eng ) [nlmuniqueid] => 101656995 [issn] => 2405-500X [essn] => 2405-5018 [pubtype] => Array ( [0] => Journal Article ) [recordstatus] => PubMed - as supplied by publisher [pubstatus] => 10 [articleids] => Array ( [0] => Array ( [idtype] => pubmed [idtypen] => 1 [value] => 41823943 ) [1] => Array ( [idtype] => doi [idtypen] => 3 [value] => 10.1016/j.jacep.2026.01.051 ) [2] => Array ( [idtype] => pii [idtypen] => 4 [value] => S2405-500X(26)00126-X ) ) [history] => Array ( [0] => Array ( [pubstatus] => received [date] => 2025/09/25 00:00 ) [1] => Array ( [pubstatus] => revised [date] => 2026/01/03 00:00 ) [2] => Array ( [pubstatus] => accepted [date] => 2026/01/27 00:00 ) [3] => Array ( [pubstatus] => medline [date] => 2026/03/13 12:40 ) [4] => Array ( [pubstatus] => pubmed [date] => 2026/03/13 12:40 ) [5] => Array ( [pubstatus] => entrez [date] => 2026/03/13 11:28 ) ) [references] => Array ( ) [attributes] => Array ( [0] => Has Abstract ) [pmcrefcount] => [fulljournalname] => JACC. Clinical electrophysiology [elocationid] => pii: S2405-500X(26)00126-X. doi: 10.1016/j.jacep.2026.01.051 [doctype] => citation [srccontriblist] => Array ( ) [booktitle] => [medium] => [edition] => [publisherlocation] => [publishername] => [srcdate] => [reportnumber] => [availablefromurl] => [locationlabel] => [doccontriblist] => Array ( ) [docdate] => [bookname] => [chapter] => [sortpubdate] => 2026/02/24 00:00 [sortfirstauthor] => Gokhale TA [vernaculartitle] => ) [41803240] => Array ( [uid] => 41803240 [pubdate] => 2026 Mar 9 [epubdate] => 2026 Mar 9 [source] => Sci Rep [authors] => Array ( [0] => Array ( [name] => Nygren S [authtype] => Author [clusterid] => ) [1] => Array ( [name] => Erdogan O [authtype] => Author [clusterid] => ) [2] => Array ( [name] => Avci P [authtype] => Author [clusterid] => ) [3] => Array ( [name] => Daniels A [authtype] => Author [clusterid] => ) [4] => Array ( [name] => Rassool R [authtype] => Author [clusterid] => ) [5] => Array ( [name] => Beheshti A [authtype] => Author [clusterid] => ) [6] => Array ( [name] => Galeano D [authtype] => Author [clusterid] => ) ) [lastauthor] => Galeano D [title] => RAG-based architectures for drug side effect retrieval using compact LLMs. [sorttitle] => rag based architectures for drug side effect retrieval using compact llms [volume] => [issue] => [pages] => [lang] => Array ( [0] => eng ) [nlmuniqueid] => 101563288 [issn] => [essn] => 2045-2322 [pubtype] => Array ( [0] => Journal Article ) [recordstatus] => PubMed - as supplied by publisher [pubstatus] => 10 [articleids] => Array ( [0] => Array ( [idtype] => pubmed [idtypen] => 1 [value] => 41803240 ) [1] => Array ( [idtype] => doi [idtypen] => 3 [value] => 10.1038/s41598-026-41495-2 ) [2] => Array ( [idtype] => pii [idtypen] => 4 [value] => 10.1038/s41598-026-41495-2 ) ) [history] => Array ( [0] => Array ( [pubstatus] => received [date] => 2025/07/18 00:00 ) [1] => Array ( [pubstatus] => accepted [date] => 2026/02/20 00:00 ) [2] => Array ( [pubstatus] => medline [date] => 2026/03/10 07:00 ) [3] => Array ( [pubstatus] => pubmed [date] => 2026/03/10 07:00 ) [4] => Array ( [pubstatus] => entrez [date] => 2026/03/10 00:22 ) ) [references] => Array ( ) [attributes] => Array ( ) [pmcrefcount] => [fulljournalname] => Scientific reports [elocationid] => doi: 10.1038/s41598-026-41495-2 [doctype] => citation [srccontriblist] => Array ( ) [booktitle] => [medium] => [edition] => [publisherlocation] => [publishername] => [srcdate] => [reportnumber] => [availablefromurl] => [locationlabel] => [doccontriblist] => Array ( ) [docdate] => [bookname] => [chapter] => [sortpubdate] => 2026/03/09 00:00 [sortfirstauthor] => Nygren S [vernaculartitle] => ) [41780166] => Array ( [uid] => 41780166 [pubdate] => 2026 Mar 13 [epubdate] => 2026 Mar 13 [source] => J Neural Eng [authors] => Array ( [0] => Array ( [name] => Wellman SM [authtype] => Author [clusterid] => ) [1] => Array ( [name] => Guzman K [authtype] => Author [clusterid] => ) [2] => Array ( [name] => Suematsu N [authtype] => Author [clusterid] => ) [3] => Array ( [name] => Thai T [authtype] => Author [clusterid] => ) [4] => Array ( [name] => Tung TH [authtype] => Author [clusterid] => ) [5] => Array ( [name] => Padilla CG [authtype] => Author [clusterid] => ) [6] => Array ( [name] => Sridhar S [authtype] => Author [clusterid] => ) [7] => Array ( [name] => Chen K [authtype] => Author [clusterid] => ) [8] => Array ( [name] => Cambi F [authtype] => Author [clusterid] => ) [9] => Array ( [name] => Kozai TDY [authtype] => Author [clusterid] => ) ) [lastauthor] => Kozai TDY [title] => Oligodendrocyte-specificfusdepletion preserves CA1 single-unit fidelity and stabilizes network dynamics during chronic recording. [sorttitle] => oligodendrocyte specificfusdepletion preserves ca1 single unit fidelity and stabilizes network dynamics during chronic recording [volume] => 23 [issue] => 2 [pages] => [lang] => Array ( [0] => eng ) [nlmuniqueid] => 101217933 [issn] => [essn] => 1741-2552 [pubtype] => Array ( [0] => Journal Article ) [recordstatus] => PubMed - indexed for MEDLINE [pubstatus] => 3 [articleids] => Array ( [0] => Array ( [idtype] => pubmed [idtypen] => 1 [value] => 41780166 ) [1] => Array ( [idtype] => doi [idtypen] => 3 [value] => 10.1088/1741-2552/ae4d8b ) ) [history] => Array ( [0] => Array ( [pubstatus] => received [date] => 2025/08/09 00:00 ) [1] => Array ( [pubstatus] => accepted [date] => 2026/03/04 00:00 ) [2] => Array ( [pubstatus] => medline [date] => 2026/03/13 12:40 ) [3] => Array ( [pubstatus] => pubmed [date] => 2026/03/05 00:39 ) [4] => Array ( [pubstatus] => entrez [date] => 2026/03/04 18:03 ) ) [references] => Array ( ) [attributes] => Array ( [0] => Has Abstract ) [pmcrefcount] => [fulljournalname] => Journal of neural engineering [elocationid] => doi: 10.1088/1741-2552/ae4d8b [doctype] => citation [srccontriblist] => Array ( ) [booktitle] => [medium] => [edition] => [publisherlocation] => [publishername] => [srcdate] => [reportnumber] => [availablefromurl] => [locationlabel] => [doccontriblist] => Array ( ) [docdate] => [bookname] => [chapter] => [sortpubdate] => 2026/03/13 00:00 [sortfirstauthor] => Wellman SM [vernaculartitle] => ) ) )

Latest News