Publications
The McGowan Institute for Regenerative Medicine maintains an active and impactful publication record that reflects the breadth and depth of our research. Faculty members and affiliated investigators regularly publish in high-impact peer-reviewed journals, advancing knowledge in tissue engineering, wound healing, cellular reprogramming, biohybrid devices, artificial intelligence in biomedicine, and related fields.
Our work appears in leading journals such as Nature, Science, PNAS, Advanced Materials, Diabetes Care, and many others. These publications document groundbreaking discoveries, from tissue nanotransfection technologies and extracellular matrix biology to novel approaches for military medicine and space biomedicine.
Explore Our Publications
View All Pitt McGowan Publications on PubMed
Searchable database of recent and historical publications authored by McGowan Institute faculty and affiliates.
You can also browse selected recent publications below (dynamically updated or manually curated list).
Exercise reduces hepatic pre-metastatic niche formation via TREM-1 signaling in kupffer cells.
Authors: Yang R, Haykal T, Tohme C, He Z, Zhang H, Gebran A, Liu S, Simmons RL, Geller DA, Yazdani HO, Tohme S Abstract Tumor-derived exosomes contribute to the formation of a hepatic pre-metastatic niche (PMN) by activating Kupffer cells (KCs) and hepatic stellate cells (HSCs), thereby promoting metastatic seeding. Whether exercise modulates exosome-driven PMN... <a class="view-article" href="https://pitt.creatotech.com/exercise-reduces-hepatic-pre-metastatic-niche-formation-via-trem-1-signaling-in-kupffer-cells/">View Article</a>
Read MoreDriving emerging technology to clinical impact.
Authors: Swanson WB, Wu DT, Yoshida M, Ambruster J, Sfeir CS, Wagner WR, Mooney DJ, Giannobile WV, Kohn DH Abstract Dental, oral, and craniofacial regenerative medicine has benefitted from fundamental scientific discoveries, yet the resulting technologies and therapies do not always generate the anticipated clinical impact. Despite robust progress and substantial investment in biomaterials and... <a class="view-article" href="https://pitt.creatotech.com/driving-emerging-technology-to-clinical-impact/">View Article</a>
Read MoreIdentification and characterization of a Fibrillin-1 derived matrikine for cardiac regeneration and repair.
Authors: Edmunds KJ, Porter EC, Lai YR, Guyette J, Williams C, Jaiganesh A, Ott H, Weinbaum JS, Black LD Abstract The development of regenerative strategies to repair the heart is of high importance. Our lab has shown that extracellular matrix derived from decellularized fetal myocardium promotes neonatal cardiomyocyte proliferation in vitro. The goal of this... <a class="view-article" href="https://pitt.creatotech.com/identification-and-characterization-of-a-fibrillin-1-derived-matrikine-for-cardiac-regeneration-and-repair/">View Article</a>
Read MoreCell-based cytokine patch for localized immunomodulation and accelerated healing in rodent and porcine wounds.
Authors: Schreib CC, Kelley EL, Audia G, Garg R, Johnson S, Fleury S, Behun MN, Vohidova D, Kulkarni M, Donnell GM, Brown BN, Badylak SF, Cohen-Karni T, Veiseh O Abstract Wounds can become chronic if the biological processes that coordinate tissue repair, including immune cell activity and matrix remodelling, become dysregulated. Current treatments mainly focus... <a class="view-article" href="https://pitt.creatotech.com/cell-based-cytokine-patch-for-localized-immunomodulation-and-accelerated-healing-in-rodent-and-porcine-wounds/">View Article</a>
Read MoreTonic dopamine sensing reveals a D2 and D3-mediated dopamine response to raclopride in Δ mice model.
Authors: Wu B, Castagnola E, Robbins E, Kaminsky M, Sanker S, McClung CA, Cui XT Abstract The circadian rhythm regulates physiological and behavioral processes, with disruptions linked to metabolic and neuropsychiatric disorders. Circadian genes play a crucial role in the regulation of dopaminergic signaling, yet the underlying molecular mechanisms remain unclear. This study investigates how... <a class="view-article" href="https://pitt.creatotech.com/tonic-dopamine-sensing-reveals-a-d2-and-d3-mediated-dopamine-response-to-raclopride-in-%ce%b4-mice-model/">View Article</a>
Read MoreRegulatory T cell attracting therapy accelerates skeletal muscle functional recovery following injury.
Authors: Borrelli MA, Warunek JJP, Ann Varghese B, Turner N, Little SR, Turnquist HR Abstract Skeletal muscle injuries are a common consequence of physical activity, repetitive movements, and trauma. Regulatory T cells (Treg) act as critical mediators of immune repair response after injury. Thus, treatments effectively targeting Treg may accelerate injury resolution. CCL22 is a... <a class="view-article" href="https://pitt.creatotech.com/regulatory-t-cell-attracting-therapy-accelerates-skeletal-muscle-functional-recovery-following-injury/">View Article</a>
Read MoreBeyond Birth Control: How Oral Contraceptives Impact Skeletal Muscle Health – a Systematic Review and Meta-Analysis.
Authors: Gilmer G, Hall AJ, Kargl CK, El-Mossier SO, Balaji S, Hussey GS, Artsen AM, Koltun KJ, Sahu A Abstract Oral contraceptive pills (OCPs) are one of the most prescribed medications, yet we lack an understanding of if and how OCPs affect non-reproductive tissues. Given the well-documented effects of sex hormones on skeletal muscle, including... <a class="view-article" href="https://pitt.creatotech.com/beyond-birth-control-how-oral-contraceptives-impact-skeletal-muscle-health-a-systematic-review-and-meta-analysis/">View Article</a>
Read MoreA Systems Biology Approach to Discovery and Validation of MicroRNA Signature Health Risks Associated with the Space Environment.
Authors: Enguita FJ, Leitão AL, Beheshti A Abstract When living organisms are exposed to the space environment, numerous changes occur that affect virtually all cellular functions and molecular pathways. One class of understudied molecules in space biomedicine is noncoding RNAs (ncRNAs), particularly microRNAs (miRNAs). Given that spaceflight induces systemic health risks, miRNAs represent natural candidates... <a class="view-article" href="https://pitt.creatotech.com/a-systems-biology-approach-to-discovery-and-validation-of-microrna-signature-health-risks-associated-with-the-space-environment/">View Article</a>
Read MoreElectrochemical modulation of host-microbe dynamics in wound healing.
Authors: Bhasme P, Singh S, Mathew Steiner SS, Roy S, Sen CK Abstract Wound healing emerges from a tightly orchestrated bioelectric landscape shaped by ion gradients, membrane potentials, and redox dynamics physical cues that direct cell migration, immune activation, and epithelial organization long before biochemical gradients take form. Recent advances reveal that electrical signals constitute... <a class="view-article" href="https://pitt.creatotech.com/electrochemical-modulation-of-host-microbe-dynamics-in-wound-healing/">View Article</a>
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