Publications
The McGowan Institute for Regenerative Medicine maintains an active and impactful publication record that reflects the breadth and depth of our research. Faculty members and affiliated investigators regularly publish in high-impact peer-reviewed journals, advancing knowledge in tissue engineering, wound healing, cellular reprogramming, biohybrid devices, artificial intelligence in biomedicine, and related fields.
Our work appears in leading journals such as Nature, Science, PNAS, Advanced Materials, Diabetes Care, and many others. These publications document groundbreaking discoveries, from tissue nanotransfection technologies and extracellular matrix biology to novel approaches for military medicine and space biomedicine.
Explore Our Publications
View All Pitt McGowan Publications on PubMed
Searchable database of recent and historical publications authored by McGowan Institute faculty and affiliates.
You can also browse selected recent publications below (dynamically updated or manually curated list).
Amine-Reactive Augmentation of Silk Fibroin Mats for Increasing Cargo Retention Capabilities.
Authors: Charles KL, Xing Y, Otto EL, Ren X, Campbell PG, Vorp DA, Weinbaum JS Abstract Silk fibroin (SF) is an ideal biomaterial for next-generation clinical wound dressings due to its biocompatibility and tunable mechanical properties. Cell therapies for wound healing have explored using SF as the base for delivering beneficial cargo; however, retention is... <a class="view-article" href="https://pitt.creatotech.com/amine-reactive-augmentation-of-silk-fibroin-mats-for-increasing-cargo-retention-capabilities/">View Article</a>
Read MoreLipid stress evolved, microbiome-based probiotics reduce lipid uptake in mice.
Authors: Acharya AP, Borrelli MA, Jurczak MJ, Krakoff J, Little SR Abstract Controlling the molecular transport of nutrients through the gut is an attractive strategy to modulate host metabolism. Herein, a technique of stress-based evolution of an individual's own microbiota to enhance lipid metabolism is presented, which is based on sequential culture of these bacteria... <a class="view-article" href="https://pitt.creatotech.com/lipid-stress-evolved-microbiome-based-probiotics-reduce-lipid-uptake-in-mice/">View Article</a>
Read MoreZeolitic imidazolate frameworks (ZIF-8) as a carrier in a topical ocular delivery system for the treatment of ocular diseases.
Authors: Harding PA, Westbay JH, Fletcher E, Fan X, DiLeo MV Abstract Current systems for topical ocular drug delivery enable non-invasive administration of therapeutics to the eye but suffer from poor permeability and bioavailability, limiting therapeutic efficacy. Metal-organic frameworks are porous, crystalline materials that can serve as drug delivery systems and may improve these shortcomings.... <a class="view-article" href="https://pitt.creatotech.com/zeolitic-imidazolate-frameworks-zif-8-as-a-carrier-in-a-topical-ocular-delivery-system-for-the-treatment-of-ocular-diseases/">View Article</a>
Read MorePartnering with Communities to Improve Diabetic Foot Ulcer Care in High-Risk Populations.
Authors: Gauvin N, Wayne B, Mathew-Steiner SS, Jones TLZ, Pop-Busui R, Spino C, Maturo F, Schmidt BM, Holmes C, Sen CK, Semere W Abstract Diabetic foot ulcers (DFUs) remain one of the most devastating complications of diabetes, accounting for over 80% of nontraumatic amputations and contributing to a 5-year mortality rate exceeding 30%. Despite significant... <a class="view-article" href="https://pitt.creatotech.com/partnering-with-communities-to-improve-diabetic-foot-ulcer-care-in-high-risk-populations/">View Article</a>
Read MoreHuman Corneal Stromal Stem Cell Treatment Reduces Established Opacities in Chronic Corneal Scarring.
Authors: Lathrop KL, Coelho JT, Chandran C, Ali SR, Geary ML, Dhaliwal DK, Jhanji V, Santra M, Yam GHF Abstract Corneal fibrosis, clinically referred to as corneal scarring, disrupts the normal architecture and transparency of the cornea and remains a major cause of visual impairment worldwide. Although corneal transplantation can restore vision, its effectiveness is... <a class="view-article" href="https://pitt.creatotech.com/human-corneal-stromal-stem-cell-treatment-reduces-established-opacities-in-chronic-corneal-scarring/">View Article</a>
Read MoreStructure- and Ligand-Based Discovery of Novel 3-Chymotrypsin-Like Protease Nonpeptidomimetic Hits.
Authors: Silva-Mendonça S, Seanego D, Jurisch C, Mottin M, Nader Motta F, S A Rodrigues B, S M Junior G, Dos Santos Carvalho AM, Muniz de Oliveira F, Sigurdardóttir S, Sunnerhagen P, Marques Dourado Bastos I, Gessner R, Chibale K, Horta Andrade C Abstract The SARS-CoV-2 3-chymotrypsin-like (3CL) protease is a key target for the... <a class="view-article" href="https://pitt.creatotech.com/structure-and-ligand-based-discovery-of-novel-3-chymotrypsin-like-protease-nonpeptidomimetic-hits/">View Article</a>
Read MoreThe Invisible Wound: Silent Focal Breach of Skin Integrity that Cascades into Systemic Dysfunction and Chronic Morbidity.
Authors: Sen CK, Roy S Abstract Barrier function of human skin maintains hydration by preventing excessive transepidermal water loss (TEWL), blocks the entry of pathogens and allergens, regulates thermal and chemical exchange with the environment, and sustains immune equilibrium. A wound arises when this barrier is breached, resulting in a loss of structural integrity and... <a class="view-article" href="https://pitt.creatotech.com/the-invisible-wound-silent-focal-breach-of-skin-integrity-that-cascades-into-systemic-dysfunction-and-chronic-morbidity/">View Article</a>
Read MoreSerum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults.
Authors: Fitz NF, Kumar A, Su Y, Sharma M, Singh S, Koldamova R, Lefterov I, Sahu A, Ambrosio F, Rosano C, Deep G Abstract Mobility decline with aging is a major health concern, associated with a higher risk for disability. Despite the prevalence of gait slowing in elderly adults, this issue has not been adequately... <a class="view-article" href="https://pitt.creatotech.com/serum-derived-extracellular-vesicles-as-biological-indicator-of-mobility-resilience-in-older-adults/">View Article</a>
Read MoreResolving differential vascular graft remodeling using longitudinal multiphoton tracking in a 3D culture platform.
Authors: Maestas DR, Murphy TR, Martinet KM, Moyston T, Min LX, Behrangzade A, Pemberton BJ, Joy J, Ye SH, Hussey GS, Azhar M, Wagner WR, Geest JPV Abstract The long-term performance of tissue-engineered scaffolds, particularly small-diameter vascular grafts, is shaped by remodeling events at the tissue-graft interface, yet these processes remain difficult to resolve longitudinally... <a class="view-article" href="https://pitt.creatotech.com/resolving-differential-vascular-graft-remodeling-using-longitudinal-multiphoton-tracking-in-a-3d-culture-platform/">View Article</a>
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